We are seeking a highly motivated and scientifically rigorous individual to join the Research and Process Development team as a Research Associate II/Sr. Research Associate. The position will report to the Associate Director of the group and will focus on developing novel mRNA formulations and development activities in the group.

Responsibilities

  • Support laboratory formulation development of mRNA drug targets entailing: production of LNP/polymer-based nanoparticles for in vivo studies, formulation characterization, and assay development
  • Focus on formulation optimization of key critical parameters with focus on potency and tolerability
  • Provide formulations and perform characterization assays /data analysis for CROs with focus on in vivo studies, drug carrier design/development, assay development.
  • Develop novel formulations for applications in local delivery
  • Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams

Qualifications

  • B.S./M.S. in Chemistry/Physical Chemistry/Chemical Engineering/Biochemistry
  • 2 – 6 years of relevant experience in drug delivery
  • Demonstrated success in nucleic acid delivery with hands-on experience in lipid nanoparticle (LNP) formulations, polymer-based nanoparticles & characterization
  • Direct experience with messenger RNA encapsulation/characterization/handling is preferred
  • Experience with developing formulations tailored for various routes of administration is advantageous
  • Proficiency in analytical techniques (HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry)
  • Demonstrated understanding and success in implementation of RNA-related analytics (Ribogreen, gel electrophoresis, capillary electrophoresis, etc.)
  • Experience in developing lyophilized formulations is a plus
  • Desire to work in a fast-paced environment
  • Excellent organizational and communication skills
  • Strong analytical and problem-solving skills
  • Works collaboratively within group as well as within interdisciplinary teams
  • Desire to work in a fast-paced environment
  • Translate Bio is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.

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