Publications

Where science translates to action

Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes.
Fenton OS, Kauffman KJ, Kaczmarek JC, et al. Adv Mater. 2017 Sep;29(33).doi: 10.1002/adma.201606944. Epub 2017 Jul 6.

Polymer-lipid nanoparticles for systemic delivery of mRNA to the lungs.
Kaczmarek JC, Patel AK, Kauffman KJ, et al. Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13808-13812. doi: 10.1002/anie.201608450. Epub 2016 Sep 30.

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo.
Kauffman KJ, Mir FF, Jhunjhunwala S, et al. Biomaterials. 2016 Dec;109:78-87. doi: 10.1016/j.biomaterials.2016.09.006. Epub 2016 Sep 25.

Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system.
DeRosa F, Guild B, Karve S, et al. Gene Ther. 2016 Oct;23(10):699-707. doi: 10.1038/gt.2016.46. Epub 2016 Jun 30.

Bioinspired alkenyl amino alcohol ionizable lipid materials for highly potent in vivo mRNA delivery.
Fenton OS, Kauffman KJ, McClellan RL, et al. Adv Mater. 2016 Apr 20;28(15):2939-2943. doi: 10.1002/adma.201505822. Epub 2016 Feb 18.

Poly(glycoamidoamine) brushes formulated nanomaterials for systemic siRNA and mRNA delivery in vivo.
Dong Y, Dorkin JR, Wang W, et al. Nano Lett. 2016 Feb 10;16(2):842-848. doi: 10.1021/acs.nanolett.5b02428. Epub 2016 Jan 13.

Optimization of lipid nanoparticle formulations for mRNA delivery in vivo with fractional factorial and definitive screening designs.
Kauffman KJ, Dorkin JR, Yang JH, et al. Nano Lett. 2015 Nov 11;15(11):7300-7306. doi: 10.1021/acs.nanolett.5b02497. Epub 2015 Oct 20.

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