Company Overview
We are a leading mRNA therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction. Using our proprietary mRNA therapeutic platform (MRT), we create mRNA that encodes functional proteins. Our mRNA is delivered to the target cell where the cell’s own machinery recognizes it and translates it, restoring or augmenting protein function to treat or prevent disease.

At Translate Bio, we’re also passionate about our five core values: Put People First, Be Approachable, Act as One, Be Tenacious, and Be Bold. These values embody our culture and underscore our mission to bring mRNA therapeutics to all.

Job Summary
We are seeking a highly motivated and scientifically rigorous candidates to lead from the bench as a Scientist/Senior Scientist in the RNA Sciences Team.  The position will focus on plasmid scale up, plasmid characterization and supporting the Translate Bio programs and collaborations.  The position will be highly collaborative and give the successful candidate a broad range of experience across functions within the organization.

Job Responsibilities
  • Design, develop and implement a robust plasmid extraction and purification process for large scale supercoiled and linearized plasmid production batches
  • Optimize and implement cell lysis/clarification and chromatographic purification methods
  • Resource raw materials and other reagents for plasmid purification process
  • Manage and mentor staff to build a highly functional plasmid scale up team
  • Support Translate Bio projects/collaborations by providing plasmid DNA in a timely manner
  • Independently design and execute decision-quality research, draft SOPs, reports and batch records
  • Prepare technical reports, presentations, and recommendations to management and other stakeholders
  • This will be primarily a lab-based position
Required Skills & Qualifications
  • Ph.D. or M.S. in a related field (e.g. Chemical Engineering, Biochemical Engineering, Biochemistry, Biotechnology) and a minimum of 2-5 years of relevant experience in a pharmaceutical, biotechnology, Contract Manufacturing Organization (CMO) or a B.S. with a minimum 8 years of relevant experience.
  • Desire to work in a team-first, fast-paced environment, learn new skills, and to efficiently solve problems
  • Attention to detail & meticulous record keeping
  • Must be proficient in large-scale plasmid purification methodologies including alkali lysis, chromatography separation (anion exchange, reverse phase, hydrophobic/ion pair interaction, size exclusion/Capto Core) and buffer exchange methods such as TFF, UF/DF, column prep and QC
  • Hands-on experience in upstream and downstream development of plasmid purification including process optimization and characterization to improve product yields and quality
  • Experience in characterization and analytical method development relevant to plasmid DNA is a plus
  • Expertise in equipment setup, troubleshooting and maintenance is mandatory and experience in GLP/GMP environment is advantageous
  • Knowledge in different cloning techniques, primer design, PCR, qPCR, capillary & gel electrophoresis, and Sanger sequence data analysis is preferred
Translate Bio is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.
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