Company Overview
We are a leading mRNA therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction. Using our proprietary mRNA therapeutic platform (MRT), we create mRNA that encodes functional proteins. Our mRNA is delivered to the target cell where the cell’s own machinery recognizes it and translates it, restoring or augmenting protein function to treat or prevent disease.

At Translate Bio, we’re also passionate about our five core values: Put People First, Be Approachable, Act as One, Be Tenacious, and Be Bold. These values embody our culture and underscore our mission to bring mRNA therapeutics to all.
 
Job Summary
We are seeking a highly motivated Senior/Research Associate to join our DMPK (Drug Metabolism and Pharmacokinetics) team in Translational Sciences Department. The successful candidate will contribute to the nanoparticle-based drug discovery and delivery efforts. She/he will conduct hands-on screening and research to advance various programs, including, but not limited to, ADME (Absorption, Distribution, Metabolism, and Excretion) assay execution and improvement, lipid bioanalysis for in vitro and in vivo studies, and new assay development as needed. This individual will primarily contribute by performing in vitro metabolism assays (in tissue fractions or primary cells), tissue binding evaluation, and LC/MS running and maintenance. As part of the team, the candidate will have the opportunity to learn other new skills.

Job Responsibilities

  • Execute in vitro metabolism and other biochemical assays. And troubleshoot as needed.
  • Improve assay throughput by implementing automation workstation.
  • LC/MS/MS bioanalysis and method development.
  • LC/MS/MS instrument maintenance and troubleshooting.
  • Perform cell culture and cell-based assays to support project needs.
  • Analyze, understand and interpret data.
  • Prepare reports and presentations of study results within groups or across the organization.
  • Work both independently and with the team to deliver reliable and reproducible results.
  • Maintain and organize experiment and data records. Track data and upload data to database.
  • Assume additional responsibilities as assigned.
Required Skills & Qualifications
  • Bachelor’s / Master’s degree with 1+ years of industry/academic experience in Biology, Biochemistry, Chemistry or similar disciplines.
  • Experience with cell culture is required.
  • Experience with in vitro drug metabolism, enzymatic, or biochemical assays or research is preferred.  Experience in any other in vitro DMPK/ADME assays is a plus.
  • Experience in LC/MS/MS operation and maintenance is preferred.
  • Experience with assay automation is preferred, but not required.
  • Experience with assay development and optimization is a plus.
  • Ability to analyze and interpret experimental data.
  • Excellent organizational and communication skills. Ability to function and communicate effectively in a highly productive, fast-paced, multi-disciplinary environment.
  • Accountable team player with great attention to detail, high enthusiasm to learn, and a strong desire for problem-solving. 
  • Ability to conduct multiple laboratory and project tasks efficiently.
  • Ability to work in a team-oriented and collaborative environment.
Translate Bio is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.
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