Company Overview
We are a leading mRNA therapeutics company developing a new class of potentially transformative medicines to treat diseases caused by protein or gene dysfunction. Using our proprietary mRNA therapeutic platform (MRT), we create mRNA that encodes functional proteins. Our mRNA is delivered to the target cell where the cell’s own machinery recognizes it and translates it, restoring or augmenting protein function to treat or prevent disease.

At Translate Bio, we’re also passionate about our five core values: Put People First, Be Approachable, Act as One, Be Tenacious, and Be Bold. These values embody our culture and underscore our mission to bring mRNA therapeutics to all.

Job Summary
Translate Bio is a preclinical biotech that is on a mission to improve the lives of people suffering from serious life-altering diseases. Translate Bio is developing transformative RNA therapies to treat diseases caused by the dysregulation of gene expression. Currently, we are developing new approaches to treat a wide range of diseases and access new targets not currently addressable by existing approaches and modalities.
 
We are seeking a highly motivated and scientifically rigorous individual to join the Research and Process Development team as a Scientist. The position will focus on developing novel formulations for systemic delivery of mRNA and formulation development activities in the group.

Job Responsibilities
  • Novel formulation development of mRNA drug targets entailing: production of LNP & polymer based nanoparticles for in vitro/in vivo studies
  • Further expand delivery capabilities for successful delivery to liver and build our intellectual property estate
  • Develop novel formulations for different ROAs for different targets
  • Work closely and build relationships with select CROs with focus on in vivo studies, drug carrier design/development, assay development
  • Focus on alternate routes of administration including local delivery, controlled release, targeted delivery etc.
  • Prepare technical reports and presentations for clear communication of scientific findings across interdisciplinary teams
Required Skills & Qualifications
  • PhD in Chemistry/Physical Chemistry/Chemical Engineering/Biochemistry
  • 0 - 4 years of relevant experience in drug delivery
  • Demonstrated success in nucleic acid delivery and the development of novel drug carriers with hands-on experience in lipid nanoparticle (LNP) formulations, polymer-based nanoparticles & characterization
  •  Direct experience with messenger RNA encapsulation/quantification/characterization/handling is preferred
  • Proficiency in analytical techniques like HPLC/UPLC, DLS, CD, zeta potential, UV-Vis and fluorescence spectrophotometry etc. is preferred
  • Understanding and success in implementation of RNA-related analytics (Ribogreen, gel electrophoresis, capillary electrophoresis, etc.) is desired.
  • Working knowledge of organic chemistry and its applications to drug delivery is preferred
  • Demonstrated thorough understanding of intracellular pathways, kinetics, biodistribution parameters, etc.
  • Previous experience designing successful drug products for various routes of administration 
  • Strong disposition for analytics (QC, methods, assay development)
  • Works collaboratively within group as well as within interdisciplinary teams
  • Demonstrated experience in working with outside CROs/CMOs
  • Manages time effectively demonstrating ability to perform multiple projects at one time
  • Desire to work in a fast-paced environment
  • Excellent organizational and communication skills
  • Strong analytical and problem-solving skills
Translate Bio is committed to equal employment opportunity. All applicants must have authorization to work in the U.S.
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